Journal: Current Issues in Molecular Biology

Article Title: Resina Draconis Promotes Diabetic Wound Healing by Regulating the AGE-RAGE Pathway to Modulate Macrophage Polarization

doi: 10.3390/cimb47090748

Figure Lengend Snippet: Molecular docking analysis of drug–target binding interactions: ( A ) Chemical structure of the main active components in RD. ( B ) Schematic diagram of the 3D structure of RAGE protein (3O3U) selected from the PDB database. ( C – H ) Binding con-formations of RAGE protein with active ingredient ligands: ( C ) LA, ( D ) LB, ( E ) LC, ( F ) LD, ( G ) 7,4′-dihydroxyflavone (7,4′-DHF), and ( H ) resveratrol (RSV). The most stable conformation with the lowest binding energy was selected as the optimal binding mode for each compound.

Article Snippet: The loureirin A (LA), loureirin B (LB), loureirin C (LC), loureirin D (LD), 7,4′-dihydroxyflavone (7,4′-DHF), and resveratrol (RSV) standards (HPLC purity ≥ 98% for all compounds) were purchased from Shanghai Yeasen Biotechnology Co., Ltd. (Shanghai, China).

Techniques: Binding Assay

Journal: Poultry Science

Article Title: Fermentation alleviates the adverse effect of peony seed meal on hepatocytes

doi: 10.1016/j.psj.2026.106807

Figure Lengend Snippet: Metabolite profiles of PSM and its changes before and after fermentation. (A) All substances in the primary classification of PSM, the numbers represent quantity and percentage respectively. (B) Changes in the number of metabolites in the primary classification before and after fermentation of PSM. (C) Changes in the number of differential metabolites in the primary classification before and after fermentation of PSM. (D) The actual content of ferulic acid, fumaric acid, gallic acid, phloretic acid and resveratrol in PSM. The data of A-C were obtained from PWTM, and data of D was obtained from HPLC. Data are presented as mean ± SD. * P < 0.05, and *** P < 0.001. n = 6 in each group. aPSM: Alcohol extract of peony seed meal. aPSMAF: Alcohol extract of peony seed meal after fermentation.

Article Snippet: The detection wavelengths of fumaric acid (standard, HPLC ≥ 98%, Shanghai Yuanye Biotechnology Co., Ltd., China), gallic acid (standard, HPLC ≥ 98%, Shanghai Yuanye Biotechnology Co., Ltd., China), phloretic acid (standard, HPLC ≥ 98%, Shanghai Yuanye Biotechnology Co., Ltd., China), resveratrol (standard, HPLC ≥98%, Shanghai Yuanye Biotechnology Co., Ltd., China) and ferulic acid (standard, HPLC ≥ 98%, Guizhou Di Technology Co., Ltd., China) are respectively 210 nm, 270 nm, 270nm, 306 nm and 300 nm.

Techniques: